Brimble Group

University of Auckland

Group of Dist. Prof. Margaret Brimble / University of Auckland / School of Chemical Sciences / School of Biological Sciences

Welcome to the Brimble group webpage. Led by Distinguished Professor Margaret Brimble, our research group leverages expertise in asymmetric synthesis, heterocyclic chemistry and organocatalysis to synthesise complex bioactive natural products. The Peptide chemistry arm of our group takes on the synthesis of glycopeptides, lipopeptides, peptidomimetics and peptide natural products.

Peptide Chemistry

Natural Products

26.06.18  “Women’s Leadership in Science and Industry: 125 Years on from the Suffragists,” A Personal Perspective Talk by Dist. Professor Margaret Brimble, Symposium hosted by Dodd-Walls Centre, University of Auckland.

09.05.2018 Prof. Brimble was elected fellow of the Royal Society (FRS), the first Female New Zealander to recieve the honor. Please find the interview with the NZ Herald here and an interview with Radio New Zealand here.

09.05.2018 Prof. Brimble was awarded the George and Christine Sosnovskaward 2018 Award in Cancer, for developing a novel innovative chemistry platform to generate fully-synthetic, self-adjuvanting cancer vaccines for the treatment of different cancers. http://www.science.auckland.ac.nz/en/about/news/news-2018/05/innovative-cancer-vaccine-technology.html

01.05.2018 Prof. Brimble was awarded the Service award from Rett New Zealand.

01.04.2018 Congratulations Iman Kavianinia for his position in the Early Career Steering Comittee of the Maurice Wilkins Centre

 

 

Highlighted Publications

“A New Family of Sesterterpenoids Isolated Around The Pacific Rim” H. J. Shirley, M. L. Jamieson, M. A. Brimble and C. D. Bray, Natural Product Reports, 2018, 35, 210-219. (Front Cover)
“Total Synthesis and Conformational Study of The Anti-tubercular Cyclic Peptide Callyaerin A Bearing a Rare Rigidifying (Z)-2,3-Diaminoacrylamide Moiety” M. A. Brimble, S. Zhang, L. M. De Leon Rodriguez, I. K. H. Leung, G. M. Cook and P. W. R. Harris, Angewandte Chemie International Edition, 2018, 57, 3631-3635.
“Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B,” S. Badrinarayanan, C. J. Squire, J. Sperry and M. A. Brimble, Organic Letters, 2017, 19, 3414-3417.
“Synthesis of Enediamino Amino Acid Analogues and Peptides” S. Zhang, L. M. De Leon Rodriguez, P. W. R. Harris and M. A. Brimble, Asian Journal of Organic Chemistry, 2017, 6, 1180-1190.
“Unexpected Direct Synthesis of N-Vinyl Amides Through Vinyl Azide-Enolate [3+2] Cycloaddition” H. Choi, H. J. Shirley, P. A. Hume, D. P. Furkert and M. A. Brimble, Angewandte Chemie International Edition, 2017, 56, 7420-7424.

Affiliations

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