Welcome to the Brimble group webpage. Led by Distinguished Professor Margaret Brimble, our research group leverages expertise in asymmetric synthesis, heterocyclic chemistry and organocatalysis to synthesise complex bioactive natural products. The Peptide chemistry arm of our group takes on the synthesis of glycopeptides, lipopeptides, peptidomimetics and peptide natural products.
15.11.2018 We are happy to receive two Marsden grants this year, firstly for “Unleashing New Generation Lanthipeptides from Nature to Combat Antimicrobial Resistance” with AIs Ghader Bashiri, Paul Harris, and Deborah Williamson of the University of Melbourne. Secondly for “Sweetening biological therapeutics-chemical synthesis of glycoprotein mimics” with PI Paul Harris, Sung Hyun Yang, and Lyn Wise (Otago).
08.11.2018 After her visit in Munich, Prof. Brimble is heading to Berlin, where she will give a talk at the 8th peptide engineering meeting, at the Freie Universitaet Berlin.
15.08.2018 Our new Class 2 toxic fumehood for microbiology and cytotoxic compounds is ready to go.
19.07.18 Prof. Brimble was invitied to hold a lecture at the 29th International Carbohydrate Symposium about her work in bioactive glycopeptides and neoglycopeptides.
14.07.18 Joining names like Rutherford, Newton and Hawking, Prof Brimble was admitted as fellow to the Royal Society, alongside others Elon Musk, Robert Grubbs and Joachim Sauer (Angela Merkels Husband).
07.07.18 Congratulations Shengping “Allan” Zhang for winning the first prize of the poster competition at the 15th Chinese International Peptide Symposium in Shenzen, China.
26.06.18 “Women’s Leadership in Science and Industry: 125 Years on from the Suffragists,” A Personal Perspective Talk by Dist. Professor Margaret Brimble, Symposium hosted by Dodd-Walls Centre, University of Auckland.
09.05.2018 Prof. Brimble was elected fellow of the Royal Society (FRS), the first Female New Zealander to recieve the honor. Please find the interview with the NZ Herald here and an interview with Radio New Zealand here.
09.05.2018 Prof. Brimble was awarded the George and Christine Sosnovskaward 2018 Award in Cancer, for developing a novel innovative chemistry platform to generate fully-synthetic, self-adjuvanting cancer vaccines for the treatment of different cancers. http://www.science.auckland.ac.nz/en/about/news/news-2018/05/innovative-cancer-vaccine-technology.html
01.05.2018 Prof. Brimble was awarded the Service award from Rett New Zealand.
|“A New Family of Sesterterpenoids Isolated Around The Pacific Rim” H. J. Shirley, M. L. Jamieson, M. A. Brimble and C. D. Bray, Natural Product Reports, 2018, 35, 210-219. (Front Cover)|
|“Total Synthesis and Conformational Study of The Anti-tubercular Cyclic Peptide Callyaerin A Bearing a Rare Rigidifying (Z)-2,3-Diaminoacrylamide Moiety” M. A. Brimble, S. Zhang, L. M. De Leon Rodriguez, I. K. H. Leung, G. M. Cook and P. W. R. Harris, Angewandte Chemie International Edition, 2018, 57, 3631-3635.|
|“Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B,” S. Badrinarayanan, C. J. Squire, J. Sperry and M. A. Brimble, Organic Letters, 2017, 19, 3414-3417.|
|“Synthesis of Enediamino Amino Acid Analogues and Peptides” S. Zhang, L. M. De Leon Rodriguez, P. W. R. Harris and M. A. Brimble, Asian Journal of Organic Chemistry, 2017, 6, 1180-1190.|
|“Unexpected Direct Synthesis of N-Vinyl Amides Through Vinyl Azide-Enolate [3+2] Cycloaddition” H. Choi, H. J. Shirley, P. A. Hume, D. P. Furkert and M. A. Brimble, Angewandte Chemie International Edition, 2017, 56, 7420-7424.|