Brimble Group

University of Auckland

Group of Dist. Prof. Dame Margaret Brimble FRS / University of Auckland / School of Chemical Sciences / School of Biological Sciences

Welcome to the Brimble group webpage. Led by Distinguished Professor Dame Margaret Brimble, our research group leverages expertise in asymmetric synthesis, heterocyclic chemistry and organocatalysis to synthesise complex bioactive natural products. The Peptide chemistry arm of our group takes on the synthesis of glycopeptides, lipopeptides, peptidomimetics and peptide natural products.

Peptide Chemistry

Natural Products

15.05.2019 Today was the official investiture for Margaret a festive day for her and her family

15.05.2019 Celebration Lunch. Congratulations to Dame Prof. Margaret Brimble

01.01.2019 Happy New Year! Good start in the new year Professor Margaret Brimble was made a Dame Companion of the New Zealand Order of Merit for services to science in the New Years Honours.

19.08.2018 Brimble Group Christmas Party 2018

06.12.2018 ChemistryWorld wrote a article featuring our new method for glycosylating synthetic erythropoietin. Please find the article here and the link to the facebook group here.

15.11.2018 We are happy to receive two Marsden grants this year, firstly for “Unleashing New Generation Lanthipeptides from Nature to Combat Antimicrobial Resistance” with AIs Ghader Bashiri, Paul Harris, and Deborah Williamson of the University of Melbourne. Secondly for “Sweetening biological therapeutics-chemical synthesis of glycoprotein mimics” with PI Paul Harris, Sung Hyun Yang, and Lyn Wise (Otago).

08.11.2018 After her visit in Munich, Prof. Brimble is heading to Berlin, where she will give a talk at the 8th peptide engineering meeting, at the Freie Universitaet Berlin.

15.08.2018 Our new Class 2 toxic fumehood for microbiology and cytotoxic compounds is ready to go.

Dr. Cameron in the new toxic fumehood

19.07.18 Prof. Brimble was invitied to hold a lecture at the 29th International Carbohydrate Symposium about her work in bioactive glycopeptides and neoglycopeptides.

14.07.18 Joining names like Rutherford, Newton and Hawking, Prof Brimble was admitted as fellow to the Royal Society, alongside others Elon Musk, Robert Grubbs and Joachim Sauer (Angela Merkels Husband).

07.07.18 Congratulations Shengping “Allan” Zhang for winning the first prize of the poster competition at the 15th Chinese International Peptide Symposium in Shenzen, China.

26.06.18  “Women’s Leadership in Science and Industry: 125 Years on from the Suffragists,” A Personal Perspective Talk by Dist. Professor Margaret Brimble, Symposium hosted by Dodd-Walls Centre, University of Auckland.

09.05.2018 Prof. Brimble was elected fellow of the Royal Society (FRS), the first Female New Zealander to recieve the honor. Please find the interview with the NZ Herald here and an interview with Radio New Zealand here.

09.05.2018 Prof. Brimble was awarded the George and Christine Sosnovskaward 2018 Award in Cancer, for developing a novel innovative chemistry platform to generate fully-synthetic, self-adjuvanting cancer vaccines for the treatment of different cancers.

01.05.2018 Prof. Brimble was awarded the Service award from Rett New Zealand.

Highlighted Publications

“A New Family of Sesterterpenoids Isolated Around The Pacific Rim” H. J. Shirley, M. L. Jamieson, M. A. Brimble and C. D. Bray, Natural Product Reports, 2018, 35, 210-219. (Front Cover)
“Total Synthesis and Conformational Study of The Anti-tubercular Cyclic Peptide Callyaerin A Bearing a Rare Rigidifying (Z)-2,3-Diaminoacrylamide Moiety” M. A. Brimble, S. Zhang, L. M. De Leon Rodriguez, I. K. H. Leung, G. M. Cook and P. W. R. Harris, Angewandte Chemie International Edition, 2018, 57, 3631-3635.
“Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B,” S. Badrinarayanan, C. J. Squire, J. Sperry and M. A. Brimble, Organic Letters, 2017, 19, 3414-3417.
“Synthesis of Enediamino Amino Acid Analogues and Peptides” S. Zhang, L. M. De Leon Rodriguez, P. W. R. Harris and M. A. Brimble, Asian Journal of Organic Chemistry, 2017, 6, 1180-1190.
“Unexpected Direct Synthesis of N-Vinyl Amides Through Vinyl Azide-Enolate [3+2] Cycloaddition” H. Choi, H. J. Shirley, P. A. Hume, D. P. Furkert and M. A. Brimble, Angewandte Chemie International Edition, 2017, 56, 7420-7424.