Brimble Group

University of Auckland

Group of Dist. Prof. Dame Margaret Brimble FRS / University of Auckland / School of Chemical Sciences / School of Biological Sciences

Welcome to the Brimble group webpage. Led by Distinguished Professor Dame Margaret Brimble, our research group leverages expertise in asymmetric synthesis, heterocyclic chemistry and organocatalysis to synthesise complex bioactive natural products. The Peptide chemistry arm of our group takes on the synthesis of glycopeptides, lipopeptides, peptidomimetics and peptide natural products.

Peptide Chemistry

Natural Products

1. “A Novel Tyrosine Hyperoxidation Enables Selective Peptide Cleavage,” S. Zhang, L. M. De Leon Rodriguez, F. F. Li, R. Huang, I. K. H. Leung, P. W. R. Harris and M. A. Brimble, Chemical Science, 2022, 13, 2753-2763. (IF = 9.8)

2. “Total Synthesis of (±)-Leonuketal,” P. S. Grant, D. P. Furkert and M. A. Brimble, Organic Letters, 2020, 22, 8735–8740. (IF = 6.6) (Selected for inclusion in “Synthesis Workshop” https://synthesis-workshop.com/

3. “On-Resin Preparation of Allenamidyl Peptides: a Versatile Chemoselective Conjugation and Intramolecular Cyclisation Tool,” A. Cameron, P.W.R. Harris and M. A. Brimble, Angewandte Chemie International Edition, 2020, 59, 18054-18061. (IF = 12.1) (VIP paper – top 10% accepted manuscripts; Hot Article, Front Cover Image).

4. “A Versatile Boc Solid Phase Synthesis of Daptomycin and Analogues using Site Specific, On-resin Ozonolysis to Install the Kynurenine Residue,” B. Xu, Y. Hermant, S.-H. Yang, P. W. R. Harris and M. A. Brimble, Chemistry: A European Journal, 2019, 25, 14101-14107. (IF = 5.2) (inside Front Cover image)

5. “A Synthetic Approach to ‘Click’ Neoglycoprotein Analogues of EPO Employing One-pot Native Chemical Ligation and CuAAC Chemistry” D. J. Lee, A. J. Cameron, T. H. Wright, P. W. R. Harris and M. A. Brimble,
Chemical Science, 2019, 10, 815-828. (IF = 9.1)
Highlighted in Chemistry World: “Erythropoietin Benefits from Controlled Sugar-Coating” by L. Ghandhi, (see: https://www.chemistryworld.com/news/erythropoietin-benefits-from-controlled-sugar-coating/3009861.article)

1. “Photoinduced Thiol–Ene Chemistry: A Versatile Toolbox for Peptide-Based Drug Design,” M. Ahangarpour, I. Kavianinia, P. W. R. Harris and M. A. Brimble, Chemical Society Reviews, 2021, 50, 898-944. (IF = 42.8) (Selected for Outside Back Cover Image)

2. “Development of Peptide-Based Antibiotics,” C. C. Hanna, Y. O. Hermant, P. W. R. Harris and M. A. Brimble, Accounts of Chemical Research,” 2021, 54, 1878–1890. (IF = 21.7) (Invited Article for Special Issue dedicated to the topic of Bacterial Multi-Drug Resistance, Guest Editors: Ryan Looper and Dale L. Boger)

3. “Molecules derived from the Extremes of Life: A Decade Later,” Z. E. Wilson and M. A. Brimble, Natural Product Reports, 2021, 38, 24-82. (IF = 11.9)

4. “Cyclic Peptide Natural Products Cross-linked via the Tryptophan Side Chain,” J. A. Swain, S. Walker, M. B. Calvert and M. A. Brimble, Natural Product Reports, 2022, 39, 410-443. (IF = 11.9)

5. “Aminovinyl Cysteine Containing Peptides: A Unique Motif That Imparts Key Biological Activity,”
E. S. Grant-Mackie, E. T. Williams, P. W. R. Harris and M. A. Brimble, Journal of the American Chemical Society Au, 2021, 1, 1527-1540. (IF = 12.35) (Invited Article)

Affiliations